Solvent:Article Title: Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
Article Snippet: Optical rotations were measured on a Rudolph Research Autopol III polarimeter (using sodium D line, 589 nm) and [α]D given in units of (degrees-mL)/(dm-g), and concentration (c) is reported in units of g/100 mL. .. Compd# a Vendor [α] (c, solvent) Ref. [α] Values LCMS Method LCMS Purity (220 nm) m/z (ESI) M + 1 45 (Gly) SigmaAldrich achiral achiral C >98%b 76.1 46 (L-Leu) ChemCruz +15° (c 2.0, 5N HCl) [α] +15.6° (c 2, 5N HCl)11 C 97%b 132.1 46-D (D-Leu) ChemImpex -14° (c 2.0, 5N HCl) [α] -15.1° (c 2, 5N HCl)11 C >98%b 132.1 47 (L-Ile) Pfaltz&Bauer +40.° (c 2.0, 5N HCl) [α] +37.5° (c 2, 5N HCl)11 C 96%b 132.2 47-D (D-Ile) CombiBlocks -38.° (c 2.0, 5N HCl) - C 95%b 132.2 48 (L-Met) TCI +24° (c 2.0, 5N HCl) [α] +23.1° (c 2, 5N HCl)11 E >98% 150.1 S7 48-D (D-Met) ChemImpex -24° (c 2.0, 5N HCl) [α] -23.9° (c 2, 5N HCl)11 E >98% 150.1 49 (L-Val) ChemImpex +26° (c 2.0, 5N HCl) [α] +26.7° (c 2, 5N HCl)11 C 98% 118.1 49-D (D-Val) ChemImpex -26° (c 2.0, 5N HCl) [α] -26.4° (c 2, 5N HCl)11 C 97% 118.1 50 (L-Phe) Acros -33° (c 2.0, water) [α] -34° (c 2, water)12 E >98% 166.1 50-D (D-Phe) ChemImpex +33° (c 2.0, water) - E >98% 166.1 51 (L-Tyr) Acros -7.9° (c 2.0, 5N HCl) - E >98% 182.1 51-D (D-Tyr) Creosalus +8.5° (c 2.0, 5N HCl) [α] +7.56° (c 2, 5N HCl)11 E >98% 182.1 52 (L-Trp) ChemImpex -30.° (c 0.50, water) - F >98% 205.1 52-D (D-Trp) ChemImpex +32° (c 0.50, water) [α] +31.7° (c 0.5, water)11 F >98% 205.1 53 (L-His) TCI -39° (c 2.0, water) [α] -38.8° (c 2, water)13 D >98% 156.1 53-D (D-His) TCI +38° (c 2.0, water) - D >98% 156.1 54 (L-Arg) SigmaAldrich +26° (c 21, 4N HCl) [α] +25.2° (c 21, 4N HCl)14 C >98% 175.2 55 (L-Lys) ChemImpex +25° (c 10., 6N HCl) [α] +27° (c 10, 6N HCl)15 H 97%b 147.1 56 (L-Asp) MP Biomedicals +25° (c 8.0, 6N HCl) [α] +24.5° (c 8, 6N HCl)16 C >98% 134.1 57 (L-Glu) JT Baker +31° (c 1.0, 6N HCl) [α] +31.6° (c 1, 6N HCl)17 C >98% 148.1 58 (1-Me-L-His) Sigma Aldrich -24° (c 0.5, water) [α] -21.2° (c 0.5, water)18 E >98% 170.1 59 (1-Bn-L-His) ChemCruz +11° (c 2.0, water + 1 equiv. .. Anhydrous MeOH, DME, DMF and THF were purchased from EMD Chemicals (Drisolv line).
Liquid Chromatography with Mass Spectroscopy:Article Title: Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
Article Snippet: Optical rotations were measured on a Rudolph Research Autopol III polarimeter (using sodium D line, 589 nm) and [α]D given in units of (degrees-mL)/(dm-g), and concentration (c) is reported in units of g/100 mL. .. Compd# a Vendor [α] (c, solvent) Ref. [α] Values LCMS Method LCMS Purity (220 nm) m/z (ESI) M + 1 45 (Gly) SigmaAldrich achiral achiral C >98%b 76.1 46 (L-Leu) ChemCruz +15° (c 2.0, 5N HCl) [α] +15.6° (c 2, 5N HCl)11 C 97%b 132.1 46-D (D-Leu) ChemImpex -14° (c 2.0, 5N HCl) [α] -15.1° (c 2, 5N HCl)11 C >98%b 132.1 47 (L-Ile) Pfaltz&Bauer +40.° (c 2.0, 5N HCl) [α] +37.5° (c 2, 5N HCl)11 C 96%b 132.2 47-D (D-Ile) CombiBlocks -38.° (c 2.0, 5N HCl) - C 95%b 132.2 48 (L-Met) TCI +24° (c 2.0, 5N HCl) [α] +23.1° (c 2, 5N HCl)11 E >98% 150.1 S7 48-D (D-Met) ChemImpex -24° (c 2.0, 5N HCl) [α] -23.9° (c 2, 5N HCl)11 E >98% 150.1 49 (L-Val) ChemImpex +26° (c 2.0, 5N HCl) [α] +26.7° (c 2, 5N HCl)11 C 98% 118.1 49-D (D-Val) ChemImpex -26° (c 2.0, 5N HCl) [α] -26.4° (c 2, 5N HCl)11 C 97% 118.1 50 (L-Phe) Acros -33° (c 2.0, water) [α] -34° (c 2, water)12 E >98% 166.1 50-D (D-Phe) ChemImpex +33° (c 2.0, water) - E >98% 166.1 51 (L-Tyr) Acros -7.9° (c 2.0, 5N HCl) - E >98% 182.1 51-D (D-Tyr) Creosalus +8.5° (c 2.0, 5N HCl) [α] +7.56° (c 2, 5N HCl)11 E >98% 182.1 52 (L-Trp) ChemImpex -30.° (c 0.50, water) - F >98% 205.1 52-D (D-Trp) ChemImpex +32° (c 0.50, water) [α] +31.7° (c 0.5, water)11 F >98% 205.1 53 (L-His) TCI -39° (c 2.0, water) [α] -38.8° (c 2, water)13 D >98% 156.1 53-D (D-His) TCI +38° (c 2.0, water) - D >98% 156.1 54 (L-Arg) SigmaAldrich +26° (c 21, 4N HCl) [α] +25.2° (c 21, 4N HCl)14 C >98% 175.2 55 (L-Lys) ChemImpex +25° (c 10., 6N HCl) [α] +27° (c 10, 6N HCl)15 H 97%b 147.1 56 (L-Asp) MP Biomedicals +25° (c 8.0, 6N HCl) [α] +24.5° (c 8, 6N HCl)16 C >98% 134.1 57 (L-Glu) JT Baker +31° (c 1.0, 6N HCl) [α] +31.6° (c 1, 6N HCl)17 C >98% 148.1 58 (1-Me-L-His) Sigma Aldrich -24° (c 0.5, water) [α] -21.2° (c 0.5, water)18 E >98% 170.1 59 (1-Bn-L-His) ChemCruz +11° (c 2.0, water + 1 equiv. .. Anhydrous MeOH, DME, DMF and THF were purchased from EMD Chemicals (Drisolv line).
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